Table 4. Identified compounds in GMMG fraction through LCMS analysis

No	Name	Formula	m/z	Mass	Group	Activity	Related compound(s)	Activity
1	4-(2-hydroxypropoxy)-3,5-dimethyl-phenol	C11H16 O3	197.12	196.11	Alcohol	• No record
2	Dioscoretine	C13 H23NO3	242.17	241.17	Fatty acid	• No record
3	2-Phenylethyl 3-methylbutanoate	C13 H18O2	207.14	206.13	Carboxylic acid	• No record
4	ML-236C	C18H26O3	291.20	290.19	Carbobicylic compound	• Anticholesteremic (Endo et al., 1976)
5	C16 Sphinganine	C16H35NO2	274.27	273.27	Lipid: Phospholipid	• Antibacteria (Reid et al., 2019)
						• Anticancer (Bagheri et al., 2018)
6	2,6-Nonadien-1-ol	C9H16O	158.15	140.12	Fatty alcohol	• Flavour compound (Kemp et al., 1974; Flath et al., 1983; McGinty et al., 2010; Api et al., 2015, 2019)
7	(–)-trans-C75	C14H22O4	272.19	254.15	Carboxylic acid	• No record
8	Cyrneine A*	C20H28O3	317.21	316.20	Terpene: Diterpene	• Neurite outgrowth (Marcotullio et al., 2006; Obara et al., 2007)	Cyathane diterpene group	• Anti-oxidant (Marcotullio et al., 2008)
								• Anti-nitric oxide (Wang et al., 2014)
								• Neurite outgrowth (Cao et al., 2018)
								• Anti-bacterial (Nitthithanasilp et al., 2018)
9	7beta-Hydroxy-lathyrol	C20H30O4	335.22	334.21	Lipid: Diterpene	• No record
10	Graveolinine*	C17H13NO3	297.12	279.09	Quinonline	Anti-angiogenesis (An et al., 2010)
						Anti-tumor and anti-platelet aggregation (Wu et al., 2003)
						Anti-AChE and anti-β amyloid (Luo et al., 2020)
11	3α-Hydroxy-4,4-bisnor-8,11,13-podocarpatriene	C15H20O	217.16	216.15	Phenol	• No record
12	Militarinone A*	C26H37NO6	460.27	459.26	Pyridine alkaloid	• Neurite outgrowth (Schmidt et al., 2002; Riese et al., 2004; Küenzi et al., 2008)	4-hydroxy-2-pyridone	• Neurite outgrowth (Schröder et al., 2015)
							(+)-N-Deoxymilitarinone A	• Neurite outgrowth (Cheng et al., 2006)
13	Eplerenone*	C24H30O6	432.24	414.21	Lactone	• Anti-inflammation (Suzuki et al., 2006; Xiao et al., 2009; Bayorh et al., 2012; Chen et al., 2013, 2018; Łabuzek et al., 2014; Wada et al., 2017; Vecchiola et al., 2020)
						• Neuroprotective (Dong et al., 2012; Wang et al., 2020)
14	Curcumenol*	C15H22O2	235.17	234.16	Curcumin	• Anti-neuroinflammation (Tanaka et al., 2008; Lo et al., 2015; Hsiao et al., 2020; Pintatum et al., 2020)	Oxycurcuminol	• Anti-stroke (Chen et al., 2018)
						• Antioxidant
						• Neuroprotective (Hamdi et al., 2015)
15	(+–)-Trihydroxy-decipiadiene	C20H32O3	321.24	320.23	Lipid: Isoprenoid	• No record
16	alhpa-Tocopheronolactone	C16H22O4	301.14	278.15	Lipid: Isoprenoid	• No record
17	N-cis-Tetradec-9Z-enoyl-L-Homoserine lactone	C18H31NO3	310.24	309.23	Lactone	• No record
18	Stigmatellin Y	C29H40O6	502.32	484.28	Phenol	• No record
19	Anandamide (20:l, n-9)	C22H43NO2	376.32	353.33	Fatty amide	• No record
20	2-Amino-14,16-dimethyloctadecan-3-ol	C20H43NO	336.32	313.33	Amino alcohol	• No record
21	2-Ethyl-dodecanoic acid	C14H28O2	229.22	228.21	Fatty acid	• No record
22	(–)-Isoamijiol	C20H32O2	322.27	304.24	Lipid: Isoprenoid	• No record
23	Palmitic amide	C16H33NO	256.26	255.26	Fatty amide	• No record
24	Coproporphyrin IV	C36H38N4O8	655.28	654.27	Porphyrin	• No record
25	Cassaidine	C24H41NO4	408.31	407.30	Tricylic diterpenoids	• No record
26	Haplophytine	C37H40N4O7	653.30	652.29	Indole alkaloid	• No record
27	24,25-Epoxy-cholesterol	C27H44O2	401.34	400.33	Desmosterol	• No record
28	MGDG(18:1(9Z)/18:1(9Z))	C45H82O10	805.58	782.59	Glycosyldiradylglycerols	• No record

Compound marked with asterisk symbol indicates compound with previously identified neuroprotective properties.
GMMG, fraction G; LCMS, liquid chromatography-mass spectrometry; AChE, acetylcholinesterase.